7-bromoquinoline-4-carboxylic acid synthesis
- Product Name:7-bromoquinoline-4-carboxylic acid
- CAS Number:31009-04-8
- Molecular formula:C10H6BrNO2
- Molecular Weight:252.06
1219834-21-5
31009-04-8
The general procedure for the synthesis of 7-bromoquinoline-4-carboxylic acid from the compound (CAS:1219834-21-5) was as follows: compound 1 (1 g) was dissolved in 10 mL of nitrobenzene and heated to reflux overnight for decarboxylation reaction. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and the resulting solid was purified by recrystallization from hexane to give the final brown solid product in 67% (570 mg) yield.
1219834-21-5
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31009-04-8
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$79.00/100mg
Yield: 67%
Reaction Conditions:
in nitrobenzeneReflux;
Steps:
5.1.2. 7-Bromoquinoline-4-carboxylic acid (2)
Decarboxylation was done by refluxing compound 1 (1 g) in10 mL of nitrobenzene overnight. The reaction mixture pressure and the resulting solid was crystallized from hexane to give brown solid in 67% yield (570 mg).
References:
Shahin, Mai I.;Roy, Joyeeta;Hanafi, Maha;Wang, Dongyao;Luesakul, Urarika;Chai, Yifeng;Muangsin, Nongnuj;Lasheen, Deena S.;Abou El Ella, Dalal A.;Abouzid, Khaled A.;Neamati, Nouri [European Journal of Medicinal Chemistry,2018,vol. 155,p. 516 - 530]
6326-79-0
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113-24-6
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31009-04-8
39 suppliers
$79.00/100mg
6326-79-0
277 suppliers
$6.00/1g
31009-04-8
39 suppliers
$79.00/100mg
52415-29-9
413 suppliers
$9.00/1g
31009-04-8
39 suppliers
$79.00/100mg