ChemicalBook CAS DataBase List 7-(Trifluoromethyl)indoline-2,3-dione

7-(Trifluoromethyl)indoline-2,3-dione synthesis

4synthesis methods

Product Name:7-(Trifluoromethyl)indoline-2,3-dione
CAS Number:391-12-8
Molecular formula:C9H4F3NO2
Molecular Weight:215.13

N-(2-trifluoromethylphenyl)-2-oxyiminoacetamide

444-93-9
5 suppliers
$158.00/500mg

391-12-8
152 suppliers
$8.00/1g

Yield:391-12-8 78%

Reaction Conditions:

with sulfuric acid at 60 - 80;

Steps:

1.1. Synthetic procedures for compounds 4a and 4b
General procedure: Concentrated sulfuric acid (95 mL) was heated in a flask at 60 C. Intermediates 2 (12 g, 52mmol) were slowly added in portions to maintain the temperature below 70 C. The temperature was then increased to 80 C. After 3 h, the solution was cooled to room temperature, and then poured into crushed ice with vigorous stirring. The precipitate was collected by filtration and dried under vacuum to provide the product 3.

References:

Wu, Chang-Chun;Wang, Bao-Lei;Liu, Jing-Bo;Wei, Wei;Li, Yu-Xin;Liu, Yang;Chen, Ming-Gui;Xiong, Li-Xia;Yang, Na;Li, Zheng-Ming [Chinese Chemical Letters,2017,vol. 28,# 6,p. 1248 - 1251] Location in patent:supporting information

FullText

444-93-9
5 suppliers
$158.00/500mg

391-12-8
152 suppliers
$8.00/1g

References