1,4-dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinecarboxylic acid dimethyl ester synthesis
- Product Name:1,4-dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinecarboxylic acid dimethyl ester
- CAS Number:70677-78-0
- Molecular formula:C17H19NO4
- Molecular Weight:301.34
Yield:70677-78-0 100%
Reaction Conditions:
with C23H3BF16N2O;ammonium acetate in toluene at 100; for 10 h;Hantzsch Dihydropyridine Synthesis;Reagent/catalyst;
Steps:
47 Preparation 47
In a 100 mL single-necked flask, 0.01 mol% of Lewis acid bicarbonate catalyst I was added (where Rf = CF3; R1,R2, R3, R4, R5, R6 = F),0.1 mol of benzaldehyde (R7 = Ph),0.1molAcetoacetate (R8 = Me; R8 = Me)0.1molAmmonium acetate,10 mL of toluene,The reaction was stirred at 100 & lt; 0 & gt; C for 10 hours,TLC followed the reaction to complete the reaction.The results of the reaction are:The yield of the product II (R7 = Ph; R8 = Me; R9 = Me) was 100%. After 10 times of the catalyst system was used, the catalytic performanceSee descent
References:
CN107141249,2017,A Location in patent:Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0111
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