1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine synthesis
- Product Name:1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine
- CAS Number:761440-65-7
- Molecular formula:C17H26N4O3
- Molecular Weight:334.41
Yield:761440-65-7 95%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 120; for 18 h;Time;
Steps:
19 1-[1-(3-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine
1-[1-(3-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine (0446) To a solution of 5-fluoro-2-nitroanisole (0.5 g, 2.92 mmol) in 3 mL of DMF was added 1-methyl-4-(piperidin)piperazine (0.536 g, 2.92 mmol) and potassium carbonate (0.808, 5.84 mmol). The mixture was heated at 120° C. for 18 h. The mixture was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was purified by chromatography to give final product as yellow solid (0.95 g, 95% yield). MS/ES+: m/z=334.
References:
ARIAD PHARMACEUTICALS, INC.;Wang, Yihan;Huang, Wei-Sheng;Liu, Shuangying;Shakespeare, William C.;Thomas, Ranny M.;Qi, Jiwei;Li, Feng;Zhu, Xiaotian;Kohlmann, Anna;Dalgarno, David C.;Romero, Jan Antoinette C.;Zou, Dong US2015/225436, 2015, A1 Location in patent:Paragraph 0446; 0511; 0.618; 0729
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761440-65-7
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448-19-1
303 suppliers
$5.00/1g
761440-65-7
66 suppliers
inquiry
41979-39-9
0 suppliers
$15.00/10mg
761440-65-7
66 suppliers
inquiry