ChemicalBook CAS DataBase List 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine

1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine synthesis

7synthesis methods

Product Name:1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine
CAS Number:761440-65-7
Molecular formula:C17H26N4O3
Molecular Weight:334.41

448-19-1 Synthesis

448-19-1
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53617-36-0 Synthesis

53617-36-0
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1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine

761440-65-7
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Yield:761440-65-7 95%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 120; for 18 h;Time;

Steps:

19 1-[1-(3-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine
1-[1-(3-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine (0446) To a solution of 5-fluoro-2-nitroanisole (0.5 g, 2.92 mmol) in 3 mL of DMF was added 1-methyl-4-(piperidin)piperazine (0.536 g, 2.92 mmol) and potassium carbonate (0.808, 5.84 mmol). The mixture was heated at 120° C. for 18 h. The mixture was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was purified by chromatography to give final product as yellow solid (0.95 g, 95% yield). MS/ES+: m/z=334.

References:

ARIAD PHARMACEUTICALS, INC.;Wang, Yihan;Huang, Wei-Sheng;Liu, Shuangying;Shakespeare, William C.;Thomas, Ranny M.;Qi, Jiwei;Li, Feng;Zhu, Xiaotian;Kohlmann, Anna;Dalgarno, David C.;Romero, Jan Antoinette C.;Zou, Dong US2015/225436, 2015, A1 Location in patent:Paragraph 0446; 0511; 0.618; 0729

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109-01-3 Synthesis