ethyl (2E)-3-chloro-2-cyano-4,4,4-trifluorobut-2- enoate synthesis
- Product Name:ethyl (2E)-3-chloro-2-cyano-4,4,4-trifluorobut-2- enoate
- CAS Number:77429-04-0
- Molecular formula:C7H5ClF3NO2
- Molecular Weight:227.57
Yield:77429-04-0 58.1%
Reaction Conditions:
Stage #1: ethyl 2-cyanoacetate;trifluoroacetic anhydridewith triethylamine in dichloromethane at -10; for 10 h;
Stage #2: with pyridine;oxalyl dichloride for 6 h;Heating;
References:
Wu, Yan-Chao;Chen, Yong-Jun;Li, Hui-Jing;Zou, Xiao-Mao;Hu, Fang-Zhong;Yang, Hua-Zheng [Journal of Fluorine Chemistry,2006,vol. 127,# 3,p. 409 - 416]
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