BenzaMide, N-[3-[1,4-dihydro-1-Methyl-7-[(6-Methyl-3-pyridinyl)aMino]-2-oxopyriMido[4,5-d]pyriMidin-3(2H)-yl]-4-Methylphenyl]-3-(trifluoroMethyl)- synthesis
- Product Name:BenzaMide, N-[3-[1,4-dihydro-1-Methyl-7-[(6-Methyl-3-pyridinyl)aMino]-2-oxopyriMido[4,5-d]pyriMidin-3(2H)-yl]-4-Methylphenyl]-3-(trifluoroMethyl)-
- CAS Number:839706-07-9
- Molecular formula:C28H24F3N7O2
- Molecular Weight:547.53
4433-40-3
224 suppliers
$6.00/250mg
839706-07-9
83 suppliers
$25.00/1mg
Yield:-
Steps:
Multi-step reaction with 7 steps
1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 1 h / 0 - 110 °C / Inert atmosphere
2: sodium iodide; potassium carbonate / acetone / 10 h / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; methanol / 1.5 h / 60 °C / Inert atmosphere
4: triethylamine / tetrahydrofuran / 1 h / 0 - 70 °C / Inert atmosphere
5: iron; ammonium chloride / methanol; tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
6: potassium carbonate / dichloromethane / 1 h / 20 °C / Inert atmosphere
7: potassium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium(0) / iso-butanol / 1 h / 100 °C / Inert atmosphere
References:
Cho, Hanna;Shin, Injae;Ju, Eunhye;Choi, Seunghye;Hur, Wooyoung;Kim, Haelee;Hong, Eunmi;Kim, Nam Doo;Choi, Hwan Geun;Gray, Nathanael S.;Sim, Taebo [Journal of Medicinal Chemistry,2018,vol. 61,# 18,p. 8353 - 8383]
7627-38-5
60 suppliers
$90.00/50 mg
839706-07-9
83 suppliers
$25.00/1mg