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5-Hydroxymethyluracil

5-Hydroxymethyluracil structure

CAS No.: 4433-40-3

Chemical Name:: 5-Hydroxymethyluracil

Synonyms: NSC 20901;AURORA KA-547;5-methyloluracil;α-HydroxythyMine;a-Hydroxythymine;uracil-5-methanol;TIMTEC-BB SBB000084;RARECHEM AH CK 0115;HYDROXYMETHYL URACIL;5-HYDROXYMETHYLURACIL

CBNumber:: CB7122987

Molecular Formula:: C5H6N2O3

Molecular Weight:: 142.11

MDL Number:: MFCD00056024

MOL File:: 4433-40-3.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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5-Hydroxymethyluracil Properties

Melting point	>300 °C(lit.)
Density	1.401±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated)
pka	8.46±0.10(Predicted)
form	Solid
color	White
Water Solubility	Soluble in water. (50 g/L ) at 20°C, DMSO, dimethyl formamide or 100% ethanol.
BRN	125482
InChI	InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)
InChIKey	JDBGXEHEIRGOBU-UHFFFAOYSA-N
SMILES	C1(=O)NC=C(CO)C(=O)N1
CAS DataBase Reference	4433-40-3(CAS DataBase Reference)
FDA UNII	590TQ3GL34
EPA Substance Registry System	2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (4433-40-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Safety Statements

22-24/25

WGK Germany

RTECS

YR0513000

TSCA

Yes

HazardClass

IRRITANT

HS Code

29335990

NFPA 704

	1
0		0

5-Hydroxymethyluracil price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	852589	5-(Hydroxymethyl)uracil 97%	4433-40-3	1g	$28.6	2024-03-01	Buy
Alfa Aesar	L01682	5-(Hydroxymethyl)uracil, 98%	4433-40-3	1g	$38.65	2024-03-01	Buy
Alfa Aesar	L01682	5-(Hydroxymethyl)uracil, 98%	4433-40-3	5g	$129.65	2024-03-01	Buy
Cayman Chemical	89360	Hydroxymethyl Uracil ≥98%	4433-40-3	250mg	$12	2024-03-01	Buy
Cayman Chemical	89360	Hydroxymethyl Uracil	4433-40-3	1000mg	$37	2024-03-01	Buy

Product number	Packaging	Price	Buy
852589	1g	$28.6	Buy
L01682	1g	$38.65	Buy
L01682	5g	$129.65	Buy
89360	250mg	$12	Buy
89360	1000mg	$37	Buy

5-Hydroxymethyluracil Chemical Properties,Uses,Production

Description

5-Hydroxymethyluracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction. It can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

Chemical Properties

White Powder

Uses

5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.

Definition

ChEBI: 5-hydroxymethyluracil is a primary alcohol that is uracil bearing a hydroxymethyl substituent at the 5-position. It has a role as a human metabolite. It is a primary alcohol and a pyrimidone. It derives from a uracil.

Biosynthesis

5-Hydroxymethyluracil is produced by the enzyme thymine dioxygenase (EC 1.14.11.6) which catalyzes the chemical reaction thymine + 2-oxoglutarate + O2 <-> 5-hydroxymethyluracil + succinate + CO2.
The 3 substrates of this enzyme are thymine, 2-oxoglutarate, and O2, whereas its 3 products are 5-hydroxymethyluracil, succinate, and CO2. The 5hmU base can also be generated by oxidation/hydroxylation of thymine by the Ten-Eleven-Translocation (TET) proteins or result from deamination of 5hmC. DNA containing 5hmU has been reported to be more flexible and hydrophilic.

Biotechnological Production

5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals.

5-Hydroxymethyluracil synthesis

Synthesis of 5-Hydroxymethyluracil from Formaldehyde and Uracil

5-Hydroxymethyluracil Preparation Products And Raw materials

Raw materials

Potassium hydroxide Formaldehyde Hydrochloric acid Uracil 4(3H)-Pyrimidinone, 2-(ethylthio)-5-(isocyanatomethyl)-

2,4(1H,3H)-Pyrimidinedione, dihydro-5,6-dihydroxy- Propanamide, N-[(formylamino)carbonyl]-2-oxo- 5-(2-Hydroxy-ethoxymethyl)-1H-pyrimidine-2,4-dione 2,4(1H,3H)-Pyrimidinedione, 5-(aminomethyl)- (9CI) 2,4(1H,3H)-Pyrimidinedione, 5-(isocyanatomethyl)-

5-hydroperoxymethyl-2'-deoxyuridine Thymidine, α-(phenylseleno)- 5-(CHLOROMETHYL)URACIL 2,4,5-TRIHYDROXYPYRIMIDINE 2(1H)-Pyrimidinone, 4-amino-5-hydroxy- (9CI)

DIHYDROTHYMINE

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Preparation Products

2,4-Dihydroxypyrimidine-5-carboxylic acid BenzaMide, N-[3-[1,4-dihydro-1-Methyl-7-[(6-Methyl-3-pyridinyl)aMino]-2-oxopyriMido[4,5-d]pyriMidin-3(2H)-yl]-4-Methylphenyl]-3-(trifluoroMethyl)-

5-Hydroxymethyluracil Suppliers

Global( 228)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sense Chemicals (Shanghai) Co., Ltd.	+86-21-52751036; +8613818977689	david.dai@sensechemicals.com	China	225	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29871	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	18478	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3889	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58

Supplier	Advantage
Sense Chemicals (Shanghai) Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58

View Lastest Price from 5-Hydroxymethyluracil manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	5-Hydroxymethyluracil 4433-40-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-05-15	5-hydroxymethyluracil 4433-40-3	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	5-Hydroxymethyluracil 4433-40-3	US $20.00 / KG	10KG	99%	100kg	Career Henan Chemical Co

5-Hydroxymethyluracil
4433-40-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-hydroxymethyluracil
4433-40-3
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

5-Hydroxymethyluracil
4433-40-3
US $20.00 / KG
99%
Career Henan Chemical Co

5-Hydroxymethyluracil Spectrum

5-Hydroxymethyluracil(4433-40-3)MS 5-Hydroxymethyluracil(4433-40-3)IR1 5-Hydroxymethyluracil(4433-40-3)IR2

4433-40-3(5-Hydroxymethyluracil)Related Search:

Silver sulfadiazine (Hydroxymethyl)urea Thymine Cytosine Sulfadiazine

Uracil Fluorocytosine Pseudouridine 5-CARBETHOXYURACIL 5-HYDROXYMETHYL-2'-DEOXYURIDINE

2,4-Dihydroxypyrimidine-5-carboxylic acid 4-methyl-5-hydroxymethyluraci 2,4-DIMETHOXY-5-PYRIMIDINECARBOXYLIC ACID 5-Hydroxymethyluracil AURORA KA-4984

AURORA KA-4986 methyl 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate AURORA KA-548

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3h)-pyrimidinedione,5-(hydroxymethyl)-4(1h 5-(hydroxymethyl)-uraci RARECHEM AH CK 0115 TIMTEC-BB SBB000084 AURORA KA-547 HYDROXYMETHYL URACIL 5-HYDROXYMETHYLURACIL 5-(HYDROXYMETHYL)URACIL HYDRATE 5-HYDROXYMETHYLURACYL 5-(HYDROXYMETHYL)-2,4(1H,3H)PYRIMIDINEDIONE 2,4-DIHYDROXY-5-HYDROXYMETHYLPYRIMIDINE 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (9CI) 5-(Hydroxymethyl)uracil,98% 5-(hydroxymethyl)pyrimidine-2,4-dione uracil-5-methanol 5-(hydroxymethyl)-1H-pyrimidine-2,4-dione 5-methyloluracil 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione, 5-(Hydroxymethyl)pyrimidine-2,4-diol 5-(hydroxyMethyl)pyriMidine-2 5-(HydroxyMethyl)-1,3-dihydropyriMidine-2,4-dione NSC 20901 α-HydroxythyMine 5-(hydroxymethyl)pyrimidine-2,4-diol 5-(Hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione 5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione|5-Hydroxymethyluracil a-Hydroxythymine 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- 5-Hydroxymethyluracil, 10 mM in DMSO 4433-40-3 PYRIMIDINE Nucleotides and Nucleosides Nucleic acids 5-FOA Bases & Related Reagents Nucleotides Building Blocks Heterocyclic Building Blocks Pyrimidines