2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile synthesis
- Product Name:2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
- CAS Number:870238-67-8
- Molecular formula:C13H15BFNO2
- Molecular Weight:247.07
105942-08-3
379 suppliers
$7.00/5g
73183-34-3
591 suppliers
$6.00/5g
870238-67-8
102 suppliers
$11.00/250mg
Yield:870238-67-8 89%
Reaction Conditions:
with palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride;anhydrous potassium acetate in 1,4-dioxane;dimethyl sulfoxide at 105; for 3 h;Inert atmosphere;
Steps:
xiv.a 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile I37
A mixture of 4-bromo-2-fluorobenzonitrile (1.0 g, 5.0 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane) (1.3 g, 5.0 mmol), potassium acetate (5.9 g, 20.0 mmol) and Pd(dppf)Cl2 (2.0 g, 1.0 mmol) in DMSO (50 ml.) and 1,4-dioxane (10 ml.) was heated at 105 °C under N2 for 3 h. [82] The mixture was diluted with EtOAc (200 ml.) and washed with water (100 ml. x 3). The organic layer was dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure and the residue was purified by column chromatography (Pet. ether/EtOAc= 100/0 to 50/1) to give the title compound (1.1 g, 89%) as a white solid, which was used directly in the next step.
References:
WO2019/243491,2019,A1 Location in patent:Page/Page column 81-82
843663-18-3
234 suppliers
$8.00/250mg
76-09-5
391 suppliers
$10.00/1g
870238-67-8
102 suppliers
$11.00/250mg
57381-51-8
186 suppliers
$6.00/1g
25015-63-8
225 suppliers
$22.39/5G
870238-67-8
102 suppliers
$11.00/250mg
394-47-8
485 suppliers
$5.00/5g