2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenyl-1-ethanone synthesis
- Product Name:2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenyl-1-ethanone
- CAS Number:87581-58-6
- Molecular formula:C13H14N2O
- Molecular Weight:214.26
Yield:87581-58-6 78%
Reaction Conditions:
with sodium carbonate;hydrazine at 0 - 80; for 0.25 h;
Steps:
5.2. General procedure for synthesis of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-aryl ethanones
General procedure: In dry mortar, acetylacetone (0.01 mol) was charged and cooled to 0 °C, and to it was added hydrazine hydrate (0.011 mol) dropwise. The resultant mixture was further ground with sodium carbonate (0.005 mol) and differently substituted acyl bromides(0.009 mol) at 80 °C for an appropriate period of time as shown in Table 1. The progress of reaction was monitored by thin layer chromatography using a mixture of petroleum ether and ethyl acetate as eluent in the ratio 5.7:1. After completion of reaction, the reaction mixture was washed well with ice cold water to remove the sodium carbonate, dried, and melting point of the product was noted.
References:
Kumar, Vinod;Kaur, Kamalneet;Karelia, Deepkamal N.;Beniwal, Vikas;Gupta, Girish Kumar;Sharma, Arun K.;Gupta, Akhilesh Kumar [European Journal of Medicinal Chemistry,2014,vol. 81,p. 267 - 276]
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