2-Propenoic acid, 3-(dimethylamino)-2-isocyano-, ethyl ester synthesis
- Product Name:2-Propenoic acid, 3-(dimethylamino)-2-isocyano-, ethyl ester
- CAS Number:87951-12-0
- Molecular formula:C8H12N2O2
- Molecular Weight:168.2
Yield:87951-12-0 92%
Reaction Conditions:
at 20;
Steps:
4.1.1.1
A mixture of 5.0 ml ethyl isocyanoacetate and 12.5 ml tert-butoxy- bis(dimethylamino)methane was stirred at ambient temperature overnight. The mixture was evaporated under reduced pressure and the resulting residue was purified by column chromatography with cyclohexane /ethyl acetate (80:20 -> 65:35) to give the intermediate 1.1. Yield: 7.1 g of 1.1 (92% of theory) Analysis: [M+H]+ = 169
References:
WO2013/156608,2013,A1 Location in patent:Page/Page column 46
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