ABC294640 synthesis
- Product Name:ABC294640
- CAS Number:915385-81-8
- Molecular formula:C23H25ClN2O
- Molecular Weight:380.91
3731-53-1
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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915385-81-8
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Yield:-
Reaction Conditions:
in tetrahydrofuranProduct distribution / selectivity;
Steps:
1
As an example, a process for the synthesis of Compound 62 is described in Scheme 1. The direct bromination of adamantane-1-carboxylic acid (1) in the presence of aluminum chloride (AlCl3) gave 3-bromide derivative (2) of 1 which was converted to (3) by the reaction of Friedel-Crafts reaction. 3 was reacted with thionyl chloride (SOCl2) to give 3-R-substituted-1-adamantanecarbonyl chlorides 4. By reaction 4 with a substituted amine, for example, 4-aminomethylpyridin (5), in THF, (6, also represented as Compound 62) and related amide compounds were obtained.
References:
APOGEE BIOTECHNOLOGY CORPORATION US2006/287317, 2006, A1 Location in patent:Page/Page column 34-35
3731-53-1
285 suppliers
$6.00/5g
1000210-73-0
0 suppliers
inquiry
915385-81-8
98 suppliers
$35.00/1mg