ADAMANTANE-1-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:ADAMANTANE-1-CARBOXYLIC ACID METHYL ESTER
- CAS Number:711-01-3
- Molecular formula:C12H18O2
- Molecular Weight:194.27
67-56-1
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828-51-3
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711-01-3
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$40.00/2 g
Yield:711-01-3 100%
Reaction Conditions:
with sulfuric acid at 130; for 0.2 h;Microwave irradiation;
Steps:
Methyl Adamantane-1-carboxylate (8)
b) Microwave Method: A mixture of adamantane-1-carboxylic acid (1 mmol),0.5 ml concentrated sulfuric acid in dry methanol was placedin a closed teflon vessel and irradiated by MW to achieve aconstant temperature of 130 °C for 12 min. Upon completionof the reaction (checked by TLC), the reaction mixture waspoured onto crushed ice to produce a white crystalline solidwhich was filtered, washed with cold water to yield quantitativelymethyl adamantane-1-carboxylate. The product wasidentical with that obtained in method a. Mp 37 °C, literature40°C [25].
References:
Al-Qawasmeh, Raed A.;Salameh, Bader A.;Alrazim, Rami;Aldamen, Murad A.;Voelter, Wolfgang [Letters in Organic Chemistry,2014,vol. 11,# 7,p. 513 - 518]
828-51-3
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18107-18-1
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711-01-3
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770-71-8
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865-33-8
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711-01-3
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67-56-1
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201230-82-2
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768-93-4
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711-01-3
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$40.00/2 g