ChemicalBook CAS DataBase List Amidinothiourea

Amidinothiourea synthesis

5synthesis methods

Product Name:Amidinothiourea
CAS Number:2114-02-5
Molecular formula:C2H6N4S
Molecular Weight:118.16

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2114-02-5
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Yield:2114-02-5 80%

Reaction Conditions:

Stage #1:cyanocarboxamidine with hydrogenchloride in water at 20;
Stage #2: with ammonium hydroxide;Sodium thiosulfate pentahydrate in water at 0; for 1 h;

Steps:

19 1-[Amino(imino)methyl]thiourea (Guanyithiourea) (A):
To a solution ofdicyandiamide (1 g, 1.9 mmol) in water (250 ml) conc. HC1 (2.38 ml) was added dropwise over aperiod of 10 minutes by maintaining the reaction temperature below 20 °C. With continued stirring, a solution of sodium thiosulfate pentahydrate (2.98 g, 1.9 mmol) in water (125 ml ) was added dropwise over 30 minutes, by then the nearly insoluble gutimine hydrogen sulfate was precipitated out. After that pH of the mixture was adjusted to 8-10 by addition of ammonium hydroxide (2.86 ml,25%) at 0 °C. The obtained precipitate was collected, washed with cold water and dried to obtain2.25 g (80%) of compound A as colorless crystals. 1H NMR (DMSO-d6): 3 7.15 (brs, 3H, NH), 6.99 (brs, 3H, NH).

References:

VYOME BIOSCIENCES PVT. LTD.;SENGUPTA, Shiladitya;GHOSH, Shamik;GHOSH, Sumana;SINHA, Mau;SADHASIVAM, Suresh;BHATTACHARYYA, Anamika;MAVUDURU, Siva Ganesh;TANDON, Nupur;KUMAR, Deepak WO2017/17631, 2017, A2 Location in patent:Paragraph 00348

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