ChemicalBook CAS DataBase List Aspartame

Aspartame synthesis

10synthesis methods

Product Name:Aspartame
CAS Number:22839-47-0
Molecular formula:C14H18N2O5
Molecular Weight:294.31

By coupling the amino acids L-phenylalanine and L-aspartic acid, and the esterification of the carboxyl group of the phenylalanine moiety to produce the methyl ester. This esterification can occur before or after coupling. The crystallized slurry is centrifuged and the resulting “wet-cake” is washed to remove impurities.

33605-76-4 Synthesis

33605-76-4
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22839-47-0
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Yield:22839-47-0 83%

Reaction Conditions:

with hydroxylamine hydrochloride in methanol;

Steps:

5 EXAMPLE 5

EXAMPLE 5 1.6 g N-Formyl-α-L-aspartyl-L-phenylalanine methyl ester (5 millimole) and 1.74 g hydroxylamine hydrochloride (25 millimole) were dissolved in 8 ml methanol, and the solution was stirred ten hours at 50° C. It then contained α-L-aspartyl-L-phenylalanine methyl ester in a yield of 83%.

References:

US4021418,1977,A

5262-07-7 Synthesis

5262-07-7
8 suppliers
$140.00/50mg

22839-47-0
834 suppliers
$5.00/1g

References

1-methyl N-L-alpha-aspartyl-3-phenyl-L-alaninate monohydrochloride

5910-52-1
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22839-47-0
834 suppliers
$5.00/1g

References

2577-90-4 Synthesis

2577-90-4
83 suppliers
$102.00/1g

22839-47-0
834 suppliers
$5.00/1g

References

Acetamide, 2-chloro-N-[(3S)-tetrahydro-2,5-dioxo-3-furanyl]-

41567-23-1
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2577-90-4 Synthesis

2577-90-4
83 suppliers
$102.00/1g

22839-47-0
834 suppliers
$5.00/1g

5910-52-1
2 suppliers
inquiry

References

Aspartame Related Search:

Methylparaben L-Phenylglycinol Methyl L-phenylalaninate hydrochloride Methyl acetate D-Phenylalanine Methyl benzoylformate L-Phenylalanine Sucralose Parathion-methyl GLYCYL-L-ALANINE