ChemicalBook CAS DataBase List Sucralose

Sucralose synthesis

8synthesis methods

Product Name:Sucralose
CAS Number:56038-13-2
Molecular formula:C12H19Cl3O8
Molecular Weight:397.63

Sucralose may be prepared by a variety of methods that involve the selective substitution of three sucrose hydroxyl groups by chlorine. Sucralose can also be synthesized by the reaction of sucrose (or an acetate) with thionyl chloride.

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Yield:56038-13-2 95%

Reaction Conditions:

with methanol;sodium methylate at 40 - 50; for 2 h;

Steps:

6

EXAMPLE 6 Synthesis of sucralose A mixture of 20 g of dry sucralose-6-acetate obtained from Example 5 and 70 ml of methanol was heated to from 40° C. to 50° C. When the reacting mixture became a clear solution, a small quantity of a 30% sodium methylate solution was added. After the mixture was stirred for 2 hours, methanol was removed under reduced pressure. The resultant mixture was diluted to a 30% mixture by adding a certain quantity of water, which was decolored and then filtered. The filtrate thus obtained was concentrated to a 65% solution, which was cooled to form crystallized sucralose. The obtained crystal was filtered and dried to give sucralose with a yield of over 95% and purity of over 98.0%.

References:

US2008/58508,2008,A1 Location in patent:Page/Page column 3