Benazepril tert-Butyl Ester synthesis
- Product Name:Benazepril tert-Butyl Ester
- CAS Number:109010-61-9
- Molecular formula:C28H36N2O5
- Molecular Weight:480.6
![Benzenebutanoicacid,a-[[(3S)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]amino]-,ethylester,(aS)-](/CAS/20180808/GIF/367909-45-3.gif)
Yield:109010-61-9 98%
Reaction Conditions:
Stage #1: (2S,3'S)-2-(2'-oxo-2',3',4',5'-tetrahydro-1H-benzo[b]azepin-3'-ylamino)-4-phenylbutyric acid ethyl esterwith potassium hydroxide;tetrabutylammomium bromide in tetrahydrofuran at 0; for 0.5 h;
Stage #2: tert-Butyl chloroacetate in tetrahydrofuran at 20; for 5 h;
References:
Chang, Ching-Yao;Yang, Teng-Kuei [Tetrahedron Asymmetry,2003,vol. 14,# 15,p. 2239 - 2245]
![Benzenebutanoic acid, α-[[(4-nitrophenyl)sulfonyl]oxy]-, ethyl ester, (αR)-](/CAS/20210305/GIF/109010-59-5.gif)
![Ethyl (R)-4-phenyl-2-[[(trifluoromethyl)sulfonyl]oxy]butyrate](/CAS/GIF/88767-98-0.gif)
88767-98-0
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