BENZYL 4-BENZYLOXYBENZOATE synthesis
- Product Name:BENZYL 4-BENZYLOXYBENZOATE
- CAS Number:56442-22-9
- Molecular formula:C21H18O3
- Molecular Weight:318.37
103-83-3
349 suppliers
$14.00/5g
100-44-7
660 suppliers
$13.50/250G
99-96-7
823 suppliers
$5.00/10g
56442-22-9
33 suppliers
$72.00/1g
Yield:56442-22-9 76%
Reaction Conditions:
with sodium iodide;potassium carbonate in acetonitrile;
Steps:
A.1 Intermediate B
1. 4-(Phenylmethoxy)benzoic acid. In a modification of the literature method [E. L. Elied, R. P. Anderson, Reactions of esters with targeting amines. I. Benzyl esters from methyl esters and benzyldimethylamine, J. Am. Chem. Soc., 1952, 74, 547-549] a mixture of 4-hydroxybenzoic acid (27.6 g, 200 mmol), chloromethylbenzene (57.0 g, 450 mmol), potassium carbonate (50 g) and sodium iodide (25 g) was boiled under reflux in acetonitrile (500 mL) for 16 h. The suspension was filtered and the solvent was evaporated from the filtrate under reduced pressure. The residue was recrystallized from ethanol to give phenylmethyl 4-(phenylmethoxy)benzoate (48.8 g, 76%).
References:
US5618528,1997,A
1112-67-0
548 suppliers
$6.00/25g
114-63-6
220 suppliers
$7.00/10g
100-44-7
660 suppliers
$13.50/250G
94-18-8
278 suppliers
$12.00/5g
56442-22-9
33 suppliers
$72.00/1g
201230-82-2
1 suppliers
inquiry
19578-68-8
113 suppliers
$24.00/5g
100-51-6
1452 suppliers
$5.00/100g
56442-22-9
33 suppliers
$72.00/1g
100-44-7
660 suppliers
$13.50/250G
99-96-7
823 suppliers
$5.00/10g
56442-22-9
33 suppliers
$72.00/1g