Biphenyl-4-acetamide synthesis
- Product Name:Biphenyl-4-acetamide
- CAS Number:63780-50-7
- Molecular formula:C14H13NO
- Molecular Weight:211.26
39889-69-5
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Yield: 84%
Reaction Conditions:
with ammonia in benzene at 20; for 20 h;
Steps:
Synthesis of N-substituted 4-biphenyl acid amides (2-16) from compound 1
General procedure: Dissolved aliphatic or aromatic primary amine in calculated amount of pyridine or 4 N NaOH (25 mL) and added this mixture in to round bottom flask containing compound 1. Dry benzene was added slowly drop wise at room temperature under constant stirring. The TLC of reactionmixture showed that the reaction becomes complete, stirring continue up to the completion of the reaction and then work up the reaction mixture with suitable solvent after approximate 20 h. Reaction mixture was taken in separatory funnel along with distilled water. Compound dissolved in the solvent, washed the solvent with water about 3-4 times to remove the basic nature of the solvent layer. The solvent layer becomes neutral, solvent layer was taken in conical flask and added MgSO4 (to absorb the moisture of solvent layer), waited for 5-10 min. Filtered the solution in round bottom flask and recovered the solvent from reaction mixture by distillation and traces of solvent with the help of vacuum pump. Concentrated residue was treated with n-hexane to complete the precipitation. The obtained white or coloured crystalline solid was filtered through Whattman filter paper (No. 42) and washed the precipitation with n-hexane about 3-4 times to remove the impurities, dried and weighed (Scheme-I).
References:
Khullar, Anju [Asian Journal of Chemistry,2019,vol. 31,# 3,p. 510 - 514]
5728-52-9
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92-91-1
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![[1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER](/CAS/GIF/59793-29-2.gif)
59793-29-2
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