bis(2-methylphenyl)-Phosphine oxide synthesis
- Product Name:bis(2-methylphenyl)-Phosphine oxide
- CAS Number:30309-80-9
- Molecular formula:C14H15OP
- Molecular Weight:230.24
36042-94-1
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Yield:-
Reaction Conditions:
with hydrogenchloride in water at 0 - 20; for 24 h;
Steps:
Synthesis of the α-aminoalkylphosphine oxides
General procedure: The synthesis of α-aminoalkylphosphine oxides startedwith the preparation of diaryl or dialkyl phosphine oxidesobtained via the oxidation of diaryl or dialkylchlorophosphines with 1 M HClaq (0 °C → r.t., 24 h).The resulting crude phosphine oxide (1 eq.) was dissolvedin toluene, and a tritylimine (1 eq.) was added. The reactionwas performed under reflux for 8 h. The volatilecomponents were removed under vacuum, and the tritylprotecting group was removed with TFA (2 h, r.t.) for thearyl derivatives or HCl (10 eq.) in MeOH (30 min, reflux)for the alkyl derivatives. The crude products were used inthe next steps of peptidyl derivative preparation. The synthesisof the α-aminoalkylphosphine oxides is outlined inFig. 9a.
References:
?upicka-S?owik, Agnieszka;Psurski, Mateusz;Grzywa, Renata;Cuprych, Monika;Ciekot, Jaros?aw;Goldeman, Waldemar;Wojaczyńska, El?bieta;Wojaczyński, Jacek;Oleksyszyn, Józef;Sieńczyk, Marcin [Investigational New Drugs,2020,vol. 38,# 5,p. 1350 - 1364]
95-46-5
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932-31-0
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6163-63-9
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