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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Brefeldin A
20350-15-6

Brefeldin A synthesis

8synthesis methods
Brefeldin A, a commonly used protein transport inhibitor, specifically and reversibly blocks protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus (Golgi). The fungus E. brefeldianum (ATCC 58665) was submerged and fermented at 25℃ with aeration and stirring to produce brefeldin A.
1-Hexanol, 5-(4-methoxyphenoxy)-, (5S)-

457100-61-7
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Brefeldin A

20350-15-6
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$28.00/1unit

-

Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: DIAD; PPh3 / tetrahydrofuran
2.1: Oxone; H2O / methanol / 60 °C
3.1: potassium hexamethyldisilylazide / 1,2-dimethoxy-ethane / 1 h / -78 °C
3.2: 1,2-dimethoxy-ethane / -78 - 20 °C
4.1: CAN; H2O / acetone
5.1: aq. NaOH / tetrahydrofuran; methanol
6.1: 61 percent / MsCl; Et3N; 2,4,6-trichlorobenzoyl chloride / 4-DMAP / toluene / Heating
7.1: 77 percent / TBAF / tetrahydrofuran / 20 °C

References:

Trost, Barry M.;Crawley, Matthew L. [Journal of the American Chemical Society,2002,vol. 124,# 32,p. 9328 - 9329]

4H-Cyclopent[f]oxacyclotridecin-4-one, 1,13-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,6,7,8,9,11a,12,13,14,14a-decahydro-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)-

177960-81-5
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Brefeldin A

20350-15-6
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$28.00/1unit

References
4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-6-methyl-1,13-bis[(4-nitrobenzoyl)oxy]-, (1R,2E,6S,10E,11aS,13S,14aR)-

104180-85-0
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Brefeldin A

20350-15-6
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$28.00/1unit

References
2-Butenoic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(1R,2S,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[(1E,6S)-6-hydroxy-1-hepten-1-yl]cyclopentyl]-, (2E,4R)-

457100-64-0
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Brefeldin A

20350-15-6
264 suppliers
$28.00/1unit

References
4H-Cyclopent[f]oxacyclotridecin-1,4(6H)-dione, 7,8,9,11a,12,13,14,14a-octahydro-13-hydroxy-6-methyl-, (2E,6S,10E,11aS,13S,14aR)-

54202-13-0
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Brefeldin A

20350-15-6
264 suppliers
$28.00/1unit

References

Brefeldin A Related Search:

Methylparaben Methyl acetate Parathion-methyl ETHYL TRANS-2-DECENOATE