Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Cabazitaxel
183133-96-2

Cabazitaxel synthesis

5synthesis methods
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).
Synthetic Routes
  • ROUTE 1

    • 202112075770168252.jpg

    Jing, Yun-rong; Zhou, Wei; Li, Wan-liang; Zhao, Lin-xiang; Wang, Yong-feng; Bioorganic & Medicinal Chemistry, Volume 22, Issue 1, Pages 194-203, Journal, 2014

  • ROUTE 2

    • 202112079228592728.jpg

    Zhang, Guoning; Fang, Weishuo Journal of Chinese Pharmaceutical Sciences Volume 21 Issue 5 Pages 472-476 Journal 2012

  • ROUTE 3

    • 202112076068236180.jpg

    Li, Caihong; Qiu, Yatao; Li, Xing; Liu, Nianjin; Yao, Zhiyi Bioorganic & Medicinal Chemistry Letters Volume 24 Issue 3 Pages 855-859 Journal; 2014

  • ROUTE 4

    • 202112071925232073.jpg

    Method for preparation of Cabazitaxel Sun, Xiaoqiang; Chen, Xin; Yang, Haitao; Miao, Chunbao Assignee Changzhou University, Peop. Rep. China 2011 Patent Information Dec 21, 2011 CN 102285947 A

  • ROUTE 5

    • 202112074347223705.jpg

    Simo, Ondrej; Vraspir, Pavel; Holas, Tomas; Jegorov, Alexandr; Gabriel, Roman. Processes for preparation of solid state forms of cabazitaxel. Assignee Plus Chemicals SA, Switz.; Teva Pharmaceuticals USA, Inc. WO 2012142117. (2012).

  • ROUTE 6

    • 202112077600089034.jpg

    Liu, Ping; Yuan, Jiandong. Method for synthesis of Cabazitaxel from 10-deacetylbaccatin III. Assignee Xintai Pharmaceutical (Suzhou) Co., Ltd., Peop. Rep. China. CN 102659721. (2012).

  • ROUTE 7

    • 202112072275062118.jpg

    Sethi, Madhuresh Kumar; Mahajan, Sanjay; Mara, Bhairaiah; Veera, Upendranath. Process for the preparation of cabazitaxel and its solvates. Assignee Mylan Laboratories Ltd., India. IN 2013CH05688. (2016).

  • ROUTE 8

    • 202112072880141278.jpg

    Hsiao, Tsungyu; Henschke, Julian Paul; Tseng, Hsinchang. Process for the preparation of cabazitaxel, and 1,3-dithiolane or 1,3-dithiane intermediates thereof. Assignee ScinoPharm Taiwan Ltd., Taiwan. US 20130116444. (2013).

202112075770168252.jpg

Jing, Yun-rong; Zhou, Wei; Li, Wan-liang; Zhao, Lin-xiang; Wang, Yong-feng; Bioorganic & Medicinal Chemistry, Volume 22, Issue 1, Pages 194-203, Journal, 2014

Cabazitaxel N-1

1354900-66-5
20 suppliers
inquiry

Cabazitaxel

183133-96-2
456 suppliers
$29.00/1mg

-
1380584-07-5

1380584-07-5
3 suppliers
inquiry

Cabazitaxel

183133-96-2
456 suppliers
$29.00/1mg

References
N',O'-(4-Methoxybenzylidene)cabazitaxel

183133-95-1
4 suppliers
inquiry

Cabazitaxel

183133-96-2
456 suppliers
$29.00/1mg

References
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-(1-ethoxyethoxy)-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

1357159-78-4
0 suppliers
inquiry

Cabazitaxel

183133-96-2
456 suppliers
$29.00/1mg

References
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-[(tetrahydro-2H-pyran-2-yl)oxy]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

1372883-35-6
1 suppliers
inquiry

Cabazitaxel

183133-96-2
456 suppliers
$29.00/1mg

References

Cabazitaxel Related Search:

Erlotinib hydrochloride MLN-8237 Imatinib Paclitaxel 10-Deacetylbaccatin III 7,10-Dimethoxy-10-DAB III 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III Cabazitaxel N-3