ChemicalBook CAS DataBase List 10-Deacetylbaccatin III

10-Deacetylbaccatin III synthesis

12synthesis methods

Product Name:10-Deacetylbaccatin III
CAS Number:32981-86-5
Molecular formula:C29H36O10
Molecular Weight:544.59

32981-90-1
49 suppliers
$498.43/5MG

32981-86-5
539 suppliers
$9.00/25mg

Yield:32981-86-5 75%

Reaction Conditions:

with water;hydrazine in ethanol at 20; for 2 h;Product distribution / selectivity;

Steps:

1.4.1

4. 10-deacetylbaccatin III (10-DAB); FIRST ALTERNATIVE; 4.1 :; 5 Grams of 7-chloroacetylbaccatin III or 7-acetylbaccatin III was dissolved in 150 ml of ethanol, and 3 mole equivalent hydrazine hydrate was added and the mixture was stirred at room temperature for 2 hours, checked by TLC, or until the reaction was completed. By means of a workup as described above, 10-deacetylbaccatin III was obtained as white crystals. Yield: >75%

References:

WO2007/101335,2007,A1 Location in patent:Page/Page column 9