ChemicalBook CAS DataBase List Choline glycerophosphate

Choline glycerophosphate synthesis

4synthesis methods

Product Name:Choline glycerophosphate
CAS Number:28319-77-9
Molecular formula:C8H20NO6P
Molecular Weight:257.22

4826-71-5 Synthesis

4826-71-5
158 suppliers
$8.00/5g

57044-25-4
245 suppliers
$6.00/1g

28319-77-9
436 suppliers
$5.00/250mg

Yield:28319-77-9 289 g

Reaction Conditions:

Stage #1: phosphorylcholine chloride, calcium saltwith sodium carbonate in water at 20; for 1 h;
Stage #2: (R)-oxiranemethanolReflux;Reagent/catalyst;Concentration;

Steps:

1 Example one

Add in the reactorPhosphorylcholine calcium salt (usually tetrahydrate) 330g and 300ml water,Stir until dissolvedA sodium carbonate solution with a concentration of 50% made of anhydrous sodium carbonate (106 g) and water was dropped and dropped at a rate of 10 ml/min. After the dropwise addition, the mixture was stirred at room temperature for 1 hour. The salt solution was passed according to the solubility of sodium chloride. Precipitation of sodium chloride in the reaction systemfilter. The filtrate was passed through a sulfonic acid ion column and eluted with water several times to HPLC without product.The solvent was distilled under reduced pressure and concentrated to a volume of 300 ml.66 g of (R)-chiral glycidol was added, and the reaction was stirred at reflux for 2-6 hours. HPLC showed no raw material, and the water was evaporated under reduced pressure and recrystallized from methanol to obtain 289 g of product. (HPLC > 99.7%)

References:

CN104628766,2017,B Location in patent:Paragraph 0044; 0045; 0046; 0047; 0048; 0049; 0050-0059

57090-45-6 Synthesis