Dapagliflozin-d5 synthesis
- Product Name:Dapagliflozin-d5
- CAS Number:1204219-80-6
- Molecular formula:C21H20ClD5O6
- Molecular Weight:413.9034
864070-18-8
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$35.00/1g
1204219-80-6
47 suppliers
$179.00/500μg
Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: triethylamine / acetonitrile / 2 h / 5 - 15 °C
2.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -65 °C / Inert atmosphere
2.2: 3 h / -65 - -55 °C
2.3: 16 h / 20 - 25 °C
3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 2 h / -30 - -10 °C / Inert atmosphere
4.1: caesium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere
References:
Xu, Ge;Lv, Binhua;Roberge, Jacques Y.;Xu, Baihua;Du, Jiyan;Dong, Jiajia;Chen, Yuanwei;Peng, Kun;Zhang, Lili;Tang, Xinxing;Feng, Yan;Xu, Min;Fu, Wei;Zhang, Wenbin;Zhu, Liangcheng;Deng, Zhongping;Sheng, Zelin;Welihinda, Ajith;Sun, Xun [Journal of Medicinal Chemistry,2014,vol. 57,# 4,p. 1236 - 1251]
864070-37-1
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59034-23-0
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1204219-80-6
47 suppliers
$179.00/500μg
![Silane,[4-[(5-broMo-2-chlorophenyl)Methyl]phenoxy](1,1-diMethylethyl)diMethyl-](/CAS/20150408/GIF/864070-19-9.gif)
864070-19-9
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1204219-80-6
47 suppliers
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1204220-63-2
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1204219-80-6
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21739-92-4
672 suppliers
$8.00/10g
1204219-80-6
47 suppliers
$179.00/500μg