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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Desloratadine
100643-71-8

Desloratadine synthesis

11synthesis methods
Desloratadine is a tricyclic H1 antagonist that is used to treat allergies.According to previously published methods described above for cyproheptadine and azatadine, the 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one – ketone, was reacted with a Grignard reagent to give the corresponding tertiary carbinol, which was dehydrated in acidic media affording the 8-chloro-11-piperidinylidene derivative – 8-chloroazatadine. The last reacted with ethyl chloroformate on reflux in benzene to give the desired compound, loratadine.
79794-75-5 Synthesis
Loratadine

79794-75-5
766 suppliers
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Desloratadine

100643-71-8
671 suppliers
$5.00/50mg

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Yield:100643-71-8 98.5%

Reaction Conditions:

in ethanol;waterReflux;Inert atmosphere;Alkaline conditions;

Steps:

1.1 Preparation of desloratadine
40g of loratadine, 40g of sodium hydroxide, 500ml of absolute ethanol and 125ml of purified water were added to the reaction flask, The reaction solution was concentrated to a large amount of solid precipitated, filtered, washed and dried to obtain desloratadine 32 g, the yield was 98.5%. The reaction was carried out under nitrogen atmosphere. (Molar ratio of loratadine to alkali is 1: 20; the ratio of purified water to anhydrous ethanol is 1: 4)

References:

ZHUHAI KINHOO PHARMACEUTICAL CO., LTD;Shang, GuanQing CN103804357, 2016, B Location in patent:Paragraph 0041-0042

FullText

38092-89-6 Synthesis
N-Methyl Desloratadine

38092-89-6
285 suppliers
$5.00/100mg

Desloratadine

100643-71-8
671 suppliers
$5.00/50mg

References
100643-73-0

100643-73-0
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Desloratadine

100643-71-8
671 suppliers
$5.00/50mg

References
N-T-BUTYL-3-METHYL PYRIDINE-2-CARBOXAMIDE

32998-95-1
53 suppliers
$95.00/500mg

Desloratadine

100643-71-8
671 suppliers
$5.00/50mg

References
3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

31255-57-9
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Desloratadine

100643-71-8
671 suppliers
$5.00/50mg

References

Desloratadine Related Search:

Benzo[b]thien-2-ylboronic acid DROPERIDOL Triacetonediamine 2,2,6,6-Tetramethyl-4-piperidinol Loratadine Cetirizine dihydrochloride N-Methyl Desloratadine