Diethyl [(2-pyridinyl)methyl]phosphonate synthesis
- Product Name:Diethyl [(2-pyridinyl)methyl]phosphonate
- CAS Number:39996-87-7
- Molecular formula:C10H16NO3P
- Molecular Weight:229.21
Yield:39996-87-7 79%
Reaction Conditions:
Stage #1: 2-chloromethylpyridine hydrochloridewith sodium hydrogencarbonate in dichloromethane;water;
Stage #2: triethyl phosphite at 150; for 5 h;Inert atmosphere;
References:
Chenna, Bala C.;Li, Linfeng;Mellott, Drake M.;Zhai, Xiang;Siqueira-Neto, Jair L.;Calvet Alvarez, Claudia;Bernatchez, Jean A.;Desormeaux, Emily;Alvarez Hernandez, Elizabeth;Gomez, Jana;McKerrow, James H.;Cruz-Reyes, Jorge;Meek, Thomas D. [Journal of Medicinal Chemistry,2020,vol. 63,# 6,p. 3298 - 3316]
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