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ChemicalBook CAS DataBase List Diethyl isoamylmalonate

Diethyl isoamylmalonate synthesis

8synthesis methods
Use isoamyl alcohol to bromide with hydrobromic acid in the presence of sulfuric acid, and then condense with diethyl malonate in the presence of sodium ethoxide to obtain Diethyl isoamylmalonate.
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 33 percent / K2CO3; Bu4NI / dimethylformamide / 48 h / 20 °C
2: 52 percent / H2 / Pd/C / ethanol / 20 °C

References:

Kar, Paramita;Rao;Nagaiah;Gurjar [Journal of the Indian Chemical Society,2005,vol. 82,# 1,p. 52 - 54]

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