DODMA synthesis
- Product Name:DODMA
- CAS Number:104162-47-2
- Molecular formula:C41H81NO2
- Molecular Weight:620.09
143-28-2
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104162-47-2
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Yield:104162-47-2 76.1%
Reaction Conditions:
with di-isopropyl azodicarboxylate;Triphenylphosphine oxide in toluene at -10 - 0; for 2 h;Reagent/catalyst;
Steps:
1.1; 1.2; 1.3; 2 method one:
To a clean and dry 5000ml three-necked flask, add oleyl alcohol (Mw=268.48, 268.5g, 1.0mol, 1.0eq),3-Dimethylamino-1,2-propanediol (Mw=119.16, 143.0g, 1.2mol, 1.2eq),Triphenylphosphine oxide (Mw=262.29, 314.7 g, 1.2 mol, 1.2 eq), toluene (2700 mL), and magnetic stirring was uniform.Diisopropyl azodicarboxylate (DIAD) (Mw=202.21, 242.7 g, 1.2 mol, 1.2 eq) was added dropwise to the reaction system at -10 to 0 °C.After the dropwise addition was completed, the reaction was kept at -10 to 0 °C for 2 h. After filtration, the filtrate was concentrated to dryness at 50° C. to obtain 612.6 g of crude DODMA with a yield of 98.8%.
References:
CN114853618,2022,A Location in patent:Paragraph 0022-0038
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35709-09-2
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104162-47-2
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$60.00/50mg
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104162-47-2
68 suppliers
$60.00/50mg