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Oleyl alcohol

Oleyl alcohol
Oleyl alcohol structure
CAS No.
143-28-2
Chemical Name:
Oleyl alcohol
Synonyms
Oceol;NOVOL;Oleol;oleyl;Satol;adol34;adol80;adol85;adol90;Lancol
CBNumber:
CB1353439
Molecular Formula:
C18H36O
Formula Weight:
268.48
MOL File:
143-28-2.mol

Oleyl alcohol Properties

Melting point:
0-5.0 °C(lit.)
Boiling point:
207 °C13 mm Hg(lit.)
Density 
0.849 g/mL at 25 °C(lit.)
vapor pressure 
10.64 hPa (195 °C)
refractive index 
n20/D 1.46(lit.)
FEMA 
4363 | CIS-9-OCTADECENOL
Flash point:
>230 °F
storage temp. 
−20°C
solubility 
Soluble in ethanol (95%), and ether; practically insoluble in water.
form 
Viscous Liquid
color 
Clear almost colorless to yellow
Water Solubility 
Miscible with alcohol and ether. Slightly miscible with carbon tetrachloride. Immiscible with water.
Merck 
14,6831
JECFA Number
1637
BRN 
1723962
Stability:
Stable. Combustible. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference
143-28-2(CAS DataBase Reference)
NIST Chemistry Reference
Oleyl Alcohol(143-28-2)
EPA Substance Registry System
9-Octadecen-1-ol, (9Z)-(143-28-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  38
Safety Statements  26-36
WGK Germany  -
RTECS  RG4120000
TSCA  Yes
HS Code  29052990
Hazardous Substances Data 143-28-2(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.

Oleyl alcohol price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 08066 Oleyl alcohol analytical standard 143-28-2 100mg $59.2 2018-11-13 Buy
Sigma-Aldrich 1478185 Oleyl alcohol United States Pharmacopeia (USP) Reference Standard 143-28-2 5x50mg $384.65 2018-11-13 Buy
TCI Chemical O0058 Oleyl Alcohol >60.0%(GC) 143-28-2 25mL $20 2018-11-22 Buy
TCI Chemical O0058 Oleyl Alcohol >60.0%(GC) 143-28-2 500mL $40 2018-11-22 Buy
Alfa Aesar A18018 Oleyl alcohol, tech. 80-85% 143-28-2 500g $53.7 2018-11-13 Buy

Oleyl alcohol Chemical Properties,Uses,Production

Chemical Properties

Colourless or light yellow liquid.

Chemical Properties

Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid fumes when heated.

Chemical Properties

Colorless to light yellow liquid; fatty aroma with animal undertones.

Uses

oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential.

Uses

Chiefly in the manufacture of its sulfuric esters which are detergents and wetting agents, as an antifoam agent; metal cutting lubricant; in carbon paper, stencil paper, printing ink; as a plasticizer; for softening and lubricating textile fabrics; carrier for medicaments.

Definition

ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).

Production Methods

Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be prepared from butyl oleate by a Bouveault–Blanc reduction with sodium and butyl alcohol. An alternative method of manufacture is by the hydrogenation of triolein in the presence of zinc chromite.

brand name

Witcohol 85 (Witco); Witcohol 90 (Witco).

Aroma threshold values

Fatty-type, medium strength odor.

Pharmaceutical Applications

Oleyl alcohol is mainly used in topical pharmaceutical formulations and has been used in transdermal delivery formulations.It has been utilized in the development of biodegradable injectable thermoplastic oligomers,and in aerosol formulations of insulin and albuterol.
Therapeutically, it has been suggested that oleyl alcohol may exhibit antitumor properties via transmembrane permeation.

Safety

Oleyl alcohol is mainly used in topical pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, contact dermatitis due to oleyl alcohol has been reported.
The results of acute oral toxicity and percutaneous studies in animals with products containing 8% oleyl alcohol indicate a very low toxicity. Formulations containing 8% or 20% oleyl alcohol administered by gastric intubation, at doses up to 10 g/kg bodyweight, caused no deaths and no toxic effects in rats.

storage

The bulk material should be stored in a well-closed container in a cool, dry, place.

Purification Methods

Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.]

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical emulsions and ointments). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Oleyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products


Oleyl alcohol Suppliers

Global( 106)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
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TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
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Oleyl alcohol Spectrum


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