ETHYL 2-(1-NAPHTHYL)-2-OXOACETATE synthesis
- Product Name:ETHYL 2-(1-NAPHTHYL)-2-OXOACETATE
- CAS Number:33656-65-4
- Molecular formula:C14H12O3
- Molecular Weight:228.24
64-17-5
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Yield:33656-65-4 62%
Reaction Conditions:
with [bis(acetoxy)iodo]benzene in dichloromethane; for 0.5 h;Reflux;
Steps:
Ethyl 1-naphthaleneglyoxylate3l
General procedure: β-Oxo-benzenepropanenitrile 1(1.0 mmol),PIDA (2.2 mmol) were dissolved in EtOH (8 mL) and stirred under refluxing for 0.5h. After the reaction was completed (monitored by TLC), thereaction mixture was concentrated under vacuum. The residue was purified by chromatographyon silica gel (20:1 petroleum ether/EtOAc) to give the product 3a-o .Thesolvent for the synthesis of 3o was MeOH.
References:
Xie, Yuanyuan;Liu, Jiwei;Huang, Yingyi;Yao, Lixia [Tetrahedron Letters,2015,vol. 56,# 24,p. 3793 - 3795] Location in patent:supporting information
90-11-9
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33656-65-4
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91-20-3
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4755-77-5
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33656-65-4
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703-55-9
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1221966-42-2
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33656-65-4
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