ethyl 2-(2,6-dichlorophenoxy)acetate synthesis
- Product Name:ethyl 2-(2,6-dichlorophenoxy)acetate
- CAS Number:40311-72-6
- Molecular formula:C10H10Cl2O3
- Molecular Weight:249.09
3336-41-2
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105-39-5
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40311-72-6
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$437.00/1g
Yield:40311-72-6 81%
Reaction Conditions:
Stage #1: 3,5-dichloro-4-hydroxybenzoic acidwith 2,4,6-trimethyl-pyridine in N,N-dimethyl-formamide at 90 - 150;
Stage #2: chloroacetic acid ethyl ester in ethyl acetate;N,N-dimethyl-formamide at 50; for 2 h;Reflux;
Steps:
2 Example 2
Add 1 mol of 3,5-dichloro-4-hydroxybenzoic acid to 150 mL of DMF, heat to 90°C, add 20 mL of 2,4,6-trimethylpyridine, heat to 120°C, and stir evenly. Decarboxylation reaction.Then the temperature was slowly raised to 150°C for reaction until no carbon dioxide was generated.Then 60 g of potash, 200 mL of ethyl acetate and 110 mL of ethyl chloroacetate were added to the above reaction solution and mixed uniformly at 50°C.Carbon dioxide overflows when the temperature is raised to 80°C, the temperature is continued, and the reaction is refluxed for 2 hours.After the reaction, 600 mL of water was added, washed, cooled to room temperature, the organic phase was separated, and the solvent was recovered by distillation under reduced pressure to obtain 201.76 g of ethyl 2,6-dichlorophenoxyacetate. The reaction yield was about 81%.
References:
CN113429308,2021,A Location in patent:Paragraph 0077-0079
87-65-0
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105-39-5
378 suppliers
$10.00/5g
40311-72-6
14 suppliers
$437.00/1g