ethyl 2,4-difluoro-5-nitrobenzoate synthesis
- Product Name:ethyl 2,4-difluoro-5-nitrobenzoate
- CAS Number:179011-37-1
- Molecular formula:C9H7F2NO4
- Molecular Weight:231.15
108928-00-3
150 suppliers
$18.00/5g
179011-37-1
17 suppliers
inquiry
Yield:179011-37-1 95%
Reaction Conditions:
with sulfuric acid;nitric acid at 0;
Steps:
59.d
(d) Ethyl 2,4-difluoro-5-nitrobenzoateCone. HNO3 (8 ml.) was added dropwise to a mixture of ethyl 2,4-difluorobenzoate (10.0 g; 53.7 mmol) in cone. H2SO4 (8 ml.) at 0 0C. After 2 h at 0 0C, the mixture was poured onto ice and extracted with EtOAc. The organic extracts were washed with saturated NaHCO3 solution (aq) and concentrated to give the sub-title compound. Yield: 1 1.8 g (95%).
References:
WO2010/100249,2010,A1 Location in patent:Page/Page column 101; 103
64-17-5
825 suppliers
$10.00/50g
153775-33-8
111 suppliers
$8.00/1g
179011-37-1
17 suppliers
inquiry
1583-58-0
436 suppliers
$6.00/5g
179011-37-1
17 suppliers
inquiry