Ethyl 3-bromo-2,4,5-trifluorobenzoylacetate synthesis
- Product Name:Ethyl 3-bromo-2,4,5-trifluorobenzoylacetate
- CAS Number:104222-46-0
- Molecular formula:C11H8BrF3O3
- Molecular Weight:325.08
125290-72-4
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104222-46-0
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Yield:-
Steps:
Multi-step reaction with 4 steps
1: 1.) LDA, 2.) 1,2-dibromotetrafluoroethane / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT
2: 45 percent / 4.5 M aq. HCl / 6 h / Heating
3: (COCl)2, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) isopropylmagnesium chloride / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT
References:
Renau, Thomas E.;Sanchez, Joseph P.;Domagala, John M. [Journal of Heterocyclic Chemistry,1996,vol. 33,# 4,p. 1407 - 1411]
104222-42-6
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