ethyl 3-broMo-5-fluorobenzoate synthesis
- Product Name:ethyl 3-broMo-5-fluorobenzoate
- CAS Number:353743-43-8
- Molecular formula:C9H8BrFO2
- Molecular Weight:247.06
176548-70-2
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64-17-5
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353743-43-8
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Yield:353743-43-8 91%
Reaction Conditions:
with sulfuric acid at 20; for 16 h;Reflux;
Steps:
43.12.1
Step 1: To a solution of 3-bromo-5-fluorobenzoic acid (2.00 g, 9.13 mmol) in absolute EtOH (20 mL) was added conc. H2504 (2 mL) at 20-25 °C. The resulting reaction mixture was heated under reflux for 16 hours. The mixture was concentrated and the residue was diluted with EtOAc (100 mL). Then the mixture was washed with saturated aqueous NaHCO3 (50 mL), brine (50 mL), dried over anhydrous Na2504 and concentrated to give ethyl 3-bromo-5-fluorobenzoate (2.10 g, yield: 91%) as a yellow oil.
References:
WO2014/186704,2014,A2 Location in patent:Paragraph 00317
24398-88-7
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353743-43-8
27 suppliers
$63.00/500mg