Ethyl 4-broMo-1-benzothiophene-2-carboxylate synthesis
- Product Name:Ethyl 4-broMo-1-benzothiophene-2-carboxylate
- CAS Number:93103-82-3
- Molecular formula:C11H9BrO2S
- Molecular Weight:285.16
360575-28-6
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623-51-8
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93103-82-3
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Yield:93103-82-3 66%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 60;Inert atmosphere;Further stages;
Steps:
14.2 Step 2:
Step 2: (0365) A three-necked flask was charged with N, N-dimethylformamide (250 ml) and potassium carbonate (51.5 g, 373 mmol). Ethyl thioglycolate (13.7 ml) was added dropwise at room temperature under a nitrogen atmosphere followed by rapid addition of compound 14-b (25.2 g, 124 mmol). The mixture was stirred at 60° C. overnight, diluted with ethyl acetate (300 ml), filtered, and the filtrate was washed with water and saturated brine, dried, concentrated and subjected to column chromatography to obtain compound 14-c (23 g, yield: 66%).
References:
US2017/158680,2017,A1 Location in patent:Paragraph 0361; 0364; 0365
![4-BROMO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID](/CAS/GIF/5194-37-6.gif)
5194-37-6
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64-17-5
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93103-82-3
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1073-06-9
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93103-82-3
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25785-10-8
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93103-82-3
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![Benzo[b]thiophene-2-carboxylic acid, 5-amino-4-bromo-, ethyl ester](/CAS/20200515/GIF/93103-81-2.gif)
93103-81-2
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93103-82-3
32 suppliers
$75.00/1g