ETHYL 4-BROMO-2-CHLOROBENZOATE synthesis
- Product Name:ETHYL 4-BROMO-2-CHLOROBENZOATE
- CAS Number:76008-74-7
- Molecular formula:C9H8BrClO2
- Molecular Weight:263.52
64-17-5
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59748-90-2
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$8.00/1g
76008-74-7
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Yield:76008-74-7 95%
Reaction Conditions:
with sulfuric acid at 0;Reflux;
Steps:
ethyl 4-bromo-2-chlorobenzoate (2)
To a mixture of 4-bromo-2-chlorobenzoic acid 1 (1.9 g, 8.1 mmol) in EtOH (50 mL) was added H2SO4 (5 mL) dropwise carefully at 0 °C. The resulting mixture was refluxed overnight. The volatile phase removed under reduced pressure. The residue was diluted with EA (100 mL), which was washed with water (2 x 50 mL) and brine, dried over sodium sulfate, filtered and concentrated. This resulted in the title compound (2.0 g, 95%) as brown oil. MS (ESI): m/z = 263.0/265.0 [M + H]+.
References:
WO2015/48662,2015,A2 Location in patent:Page/Page column 118-119
5798-75-4
197 suppliers
$6.00/5g
76008-74-7
28 suppliers
$120.18/250mgs: