ethyl 5-broMo-2-iodobenzoate synthesis
- Product Name:ethyl 5-broMo-2-iodobenzoate
- CAS Number:450412-27-8
- Molecular formula:C9H8BrIO2
- Molecular Weight:354.97
21740-00-1
332 suppliers
$8.00/5g
450412-27-8
30 suppliers
$248.00/1g
Yield:450412-27-8 100%
Reaction Conditions:
with oxalyl dichloride in dichloromethane at 40; for 0.5 h;
Steps:
17.1
Step 1 5-Bromo-2-iodo-benzoic acid ethyl ester; 5-Bromo-2-iodo-benzoic acid (25.Og, 76.47 mol) was dissolved in CH2Cl2 (75 ml) at room temperature. Oxalyl chloride (14.5 ml, 152.94 mmol) was added and the mixture was stirred at 4O0C for 30 minutes. The mixture was allowed to cool to room temperature and EtOH (6.69 ml, 114.71 mmol) was added. The mixture was concentrated under reduced pressure to give 27.2 g (quantitative) of 5-bromo-2-iodo-benzoic acid ethyl ester as a yellow crystalline solid.
References:
WO2008/55847,2008,A1 Location in patent:Page/Page column 86
64-17-5
757 suppliers
$10.00/50g
21740-00-1
332 suppliers
$8.00/5g
450412-27-8
30 suppliers
$248.00/1g
1829-28-3
96 suppliers
$9.00/5g
450412-27-8
30 suppliers
$248.00/1g