ethyl DL-methionate synthesis
- Product Name:ethyl DL-methionate
- CAS Number:452-95-9
- Molecular formula:C7H15NO2S
- Molecular Weight:177.26
Yield:-
Reaction Conditions:
in methanol
Steps:
8 Cleavage of Resin-bound Tert-alkyl Carbamate (8h(n=2))
EXAMPLE 8 Cleavage of Resin-bound Tert-alkyl Carbamate (8h(n=2)) Acetyl chloride (10.2 mL, 0.14 mol) was added to a 3/2 CH2 Cl2 /MeOH (40 mL) solution, cooled to 0° C. The resin 8h(n=2) (36 mg) was treated with the HCl solution (2.5 mL) for 4.5 hours and filtered. The resin was rinsed with CH2 Cl2 (4 times), and the filtrates evaporated and dried (vacuum, overnight) to give back methionine ethyl ester (7h), as its HCl salt (8 mg). A 1 H NMR spectrum of the cleaved ammonium hydrochloride 7h. HCl was identical to the one obtained from an authentic sample of methionine ethyl ester.HCl.
References:
Warner-Lambert Company US5932696, 1999, A
