ChemicalBook CAS DataBase List Ethyl isobutyrate

Ethyl isobutyrate synthesis

7synthesis methods

Product Name:Ethyl isobutyrate
CAS Number:97-62-1
Molecular formula:C6H12O2
Molecular Weight:116.16

By esterification of ethanol with isobutyric acid under azeotropic conditions.

64-17-5 Synthesis

64-17-5
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$10.00/50g

79-31-2
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$18.00/25mL

97-62-1
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$16.60/100G

Yield:97-62-1 68.9%

Reaction Conditions:

with toluene-4-sulfonic acid in cyclohexane;Reflux;

Steps:

To a solution of isobutyric acid (88.0 g, 1 mol) in ethanol(90 mL) and cyclohexane (20 mL), p-toluenesulfonic acid(1.8 g, 2%) was added. The reaction was refluxed until nowater appeared in water separator. The mixture was cooleddown and washed by water, saturated sodium bicarbonateaqueous solution and saturated sodium chloride,respectively, then dried over anhydrous magnesium sulfate.After cyclohexane was removed by distillation under vacuum,then 109-113 °C distillate was collected to get ethylisobutyrate (58.0 g, 0.5 mol). Yield: 68.9%.

References:

Li, Zhenyu;Cao, Yuan;Zhan, Peng;Pannecouque, Christophe;Balzarini, Jan;De Clercq, Erik;Shen, Yuemao;Liu, Xinyong [Medicinal Chemistry,2013,vol. 9,# 7,p. 968 - 973]

64-17-5 Synthesis

64-17-5
692 suppliers
$10.00/50g

96-05-9 Synthesis