4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester synthesis
- Product Name:4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- CAS Number:1421312-34-6
- Molecular formula:C18H15NO4
- Molecular Weight:309.32
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Yield:1421312-34-6 95.23%
Reaction Conditions:
with Pd/C;hydrogen;sodium carbonate in ethyl acetate at 40; under 7500.75 Torr; for 15 h;Pressure;Temperature;
Steps:
1-2 Preparation of compound 4
Add compound 3 (90g, 0.246mol), 500ml ethyl acetate, sodium carbonate (14.52g, 0.132mol), Pd/C (13.5g) into the hydrogenation reactor in sequence, and pressurize the hydrogen to 1.0MPa after nitrogen replacement. The reaction solution was heated to 40°C and reacted for 15 hours. TLC plate detected that the reaction was completed. The reaction solution was filtered and concentrated to obtain 72 g of crude compound 4, with a total yield of 95.23% and an HPLC purity of 99.61%.
References:
CN108017583,2021,B Location in patent:Paragraph 0027; 0034-0036; 0040; 0045-0047
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