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ChemicalBook >> CAS DataBase List >>4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Structure
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester structure
CAS No.
1421312-34-6
Chemical Name:
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Synonyms
methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate;Fg6347;ROXA-019;fg-4592 int 2;RSYY(Roxadustat)-17;Fg-4592/FG4592 int 2;Roxadustat Impurity 34;Roxadustat impurity rst3;Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate;methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylat...
CBNumber:
CB42756260
Molecular Formula:
C18H15NO4
Molecular Weight:
309.32
MDL Number:
MFCD30489347
MOL File:
1421312-34-6.mol
Last updated:2023-12-21 13:02:20
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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Properties

Boiling point 537.3±45.0 °C(Predicted)
Density 1.289±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere, 2-8°C
pka 6.24±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H302-H315-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 2731DU Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 1421312-34-6 5g $593 2021-12-16 Buy
Alichem 1421312346 Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 1421312-34-6 10g $614.8 2021-12-16 Buy
Crysdot CD11260325 Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 97% 1421312-34-6 1g $120 2021-12-16 Buy
Chemenu CM263516 Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 95+% 1421312-34-6 5g $337 2021-12-16 Buy
Crysdot CD11260325 Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 97% 1421312-34-6 5g $360 2021-12-16 Buy
Product number Packaging Price Buy
2731DU 5g $593 Buy
1421312346 10g $614.8 Buy
CD11260325 1g $120 Buy
CM263516 5g $337 Buy
CD11260325 5g $360 Buy

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties,Uses,Production

Uses

4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.

Preparation

Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution.  Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester synthesis

1509958-20-6
1421312-34-6
Synthesis of 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester from FG-4592 intermediate 8

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

FG-4592 intermediate7 FG-4592 intermediate 8 methyl 1-bromo-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate methyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Methyl boronic acid pinacol ester
FG-4592 interMediate methyl (triphenylphosphoranylidene)acetate Acetyl chloride Dimethyl sulfoxide Trimethylboroxine
TETRAMETHYLTIN Methylboronic acid Methylmagnesium chloride

1of3

Preparation Products

methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Suppliers

Global( 133)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangsu Yutian pharmaceutical Co.,Ltd.
+undefined-0518-86098006 +undefined19851887368 lvan.hui@jsytsw.com China 80 58
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4242 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		+86-21-68900963 sales@jinghaopharma.com CHINA 153 58
Supplier Advantage
Jiangsu Yutian pharmaceutical Co.,Ltd.
58
Hangzhou ICH Biofarm Co., Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Accela ChemBio Inc. 		58
Shochem(Shanghai) Co.,Ltd 		58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		58

View Lastest Price from 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester pictures 2023-11-01 3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester
1421312-34-6
 US $0.00 / kg 1kg 99% 200kg Hangzhou ICH Biofarm Co., Ltd
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester pictures 2022-10-14 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
1421312-34-6
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
fg-4592 int 2 pictures 2019-09-06 fg-4592 int 2
1421312-34-6
 US $5.50 / KG 2KG 96%-99% 100kg Career Henan Chemical Co
  • fg-4592 int 2 pictures
  • fg-4592 int 2
    1421312-34-6
  • US $5.50 / KG
  • 96%-99%
  • Career Henan Chemical Co

1421312-34-6(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester)Related Search:

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid ethyl ester Roxadustat FG-4592 interMediate
fg-4592 int 2 1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Fg-4592/FG4592 int 2 ROXA-019 methyl 4-hydroxy-1-methyl-7-pheno1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid xyisoquinoline-3-carboxylate 3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, methyl ester 4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate Roxadustat Impurity 34 Fg6347 methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylat... methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate RSYY(Roxadustat)-17 Roxadustat impurity rst3 1421312-34-6 API