Fluorescein synthesis
- Product Name:Fluorescein
- CAS Number:2321-07-5
- Molecular formula:C20H12O5
- Molecular Weight:332.31
A second method to prepare fluorescein uses methanesulfonic acid as a Br?nsted acid catalyst. This route has a high yield under milder conditions.
Yield:2321-07-5 95%
Reaction Conditions:
with Zn0.95*Ti0.05O in neat (no solvent) at 160; for 1.33 h;Catalytic behavior;Green chemistry;Reagent/catalyst;Temperature;Time;
Steps:
2.3 General experimental procedure for fluorescein synthesis
General procedure: In a typical experimental procedure, phthalic anhydride (1 mmol), resorcinol (2 mmol) and Zn0.950Ti0.050O (10 mol%) catalyst were heated with constant stirring for 1.33h at 160°C and the progress of the reaction was monitored by TLC. After the completion of reaction, the reaction mixture was dissolved in 1N NaOH (10 mL) and the catalyst was separated using centrifugation. The filtrate was acidified using 1N HCl until the solution was neutralized. During neutralization, the precipitation of the dye was observed which was further purified by recrystallization with methanol.
References:
Jadhav, Nirajkumar H.;Shinde, Dnyaneshwar R.;Sakate, Sachin S.;Rasal, Nishant K.;Pawar, Ramdas A. [Catalysis Communications,2019,vol. 120,p. 17 - 22]
596-09-8
217 suppliers
$33.60/5G
2321-07-5
347 suppliers
$6.00/25g
![3',6'-Dihydroxy-6-isothiocyanatospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one](/CAS/GIF/3326-31-6.gif)
3326-31-6
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2321-07-5
347 suppliers
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3326-34-9
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2321-07-5
347 suppliers
$6.00/25g
