ChemicalBook CAS DataBase List Furan-2-carbohydrazide

Furan-2-carbohydrazide synthesis

9synthesis methods

Product Name:Furan-2-carbohydrazide
CAS Number:3326-71-4
Molecular formula:C5H6N2O2
Molecular Weight:126.11

609-38-1

627-70-3

3326-71-4

General procedure for the synthesis of 2-furancarbohydrazide from furan-2-carboxamide and 4-methyl-3-penten-2-one hydrazone: 111.1 g of furan-2-carboxamide was placed in a four-necked flask fitted with a stirrer, a dropping funnel, a thermometer, and a distillation column, and 224 g of acetone acridine was added. Stirring was turned on and the reaction mixture was heated to 100 to 120 °C to ensure complete dissolution of furan-2-carboxamide in acetone acridazine. Subsequently, 70 ml of water was slowly added through a dropping funnel to maintain the reaction temperature between 100 °C and 120 °C. The ammonia produced during the reaction was exported through a distillation column and the ammonia was recovered by condensation at 54°C to 58°C. The condensed water vapor was returned to the reaction flask to continue participating in the reaction. After the water droplet addition was completed, heating of the reaction mixture was continued. The progress of the reaction was monitored by analyzing the amount of furan-2-carboxamide in the reaction solution. Once the furan-2-carboxamide was fully reacted, the flask was distilled with acetone and water fully connected under nitrogen protection. The residual solid in the flask was recrystallized with ethanol and dried to give 119.6 g of 2-furancarboxamide.

609-38-1
107 suppliers
$19.00/1g

627-70-3
25 suppliers
$95.00/1g

3326-71-4
223 suppliers
$15.00/5mg

Yield:3326-71-4 119.6 g

Reaction Conditions:

with water at 100 - 120;

Steps:

3
Furan-2- carboxamide 111.1g,224g of acetone azine placed with stirring,Dropping funnel,Thermometer and distillation column in a four-necked flask,The upper part of the receiver of the distillation column is connected with a conduit to absorb ammonia gas;Open the stir,The solution was heated to a temperature of 100 to 120 ° C,Carboxamide be 2-furyl all dissolved in acetone azine,70 ml of water was slowly added dropwise to a four-necked flask,Control reaction temperature of 100 ~ 120 ,When the gas produced by the reaction enters the rectification column,In the column temperature 54 ~ 58 under the acetone and recovery of ammonia,Water vapor condensed back to the flask to continue to participate in the reaction;After the water dripping continues to heat the reaction,The contents of 2-furancarboxamide in the reaction solution were analyzed,After the reaction of 2-furancarboxamide in the reaction solution was completed,The flask was connected to nitrogen and water in acetone with full vacuum distilled,The solid matter in the flask was recrystallized from ethanol,And dried to give 2-furoyl hydrazide 119.6g

References:

Chongqing Licheng Environmental Protection Technology Co., Ltd.;Liu Huan CN106967020, 2017, A Location in patent:Paragraph 0010

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