Guanidine, (4-phenyl-2-thiazolyl)- synthesis
- Product Name:Guanidine, (4-phenyl-2-thiazolyl)-
- CAS Number:2507-81-5
- Molecular formula:C10H10N4S
- Molecular Weight:218.28
98-86-2
739 suppliers
$9.00/5g
2507-81-5
13 suppliers
$315.00/500mg
Yield:2507-81-5 96%
Reaction Conditions:
with Oxone;sodium bromide in methanol at 60; for 2 h;
Steps:
4 Example 4: Synthesis of N-(4-phenyl-1,3-thiazol-2-yl)guanidine (Formula 11)
Acetophenone (0.48 g, 4.0 mmol)Dissolved in MeOH (40 mL),Add Oxone (2.70 g, 4.4mmol) sequentiallyAnd NaBr (0.45 g, 4.4 mmol),Slowly raise the temperature to 60 and reflux for 2h,Add amidinothiourea (0.47 g, 4.0 mmol) toInto the mixture.After 2h, the reaction is complete,The reaction mixture is filtered,The filtrate was taken and concentrated in vacuo.Dissolve the crude product in water,Adjust the pH to 8-9 with ammonia water,There is solid precipitation,Suction filtration, take the filter cake, and dry.Finally, the crude product obtained is recrystallized with MeOH,The product N-(4-phenyl-1,3-thiazol-2-yl)guanidine (0.84 g) with the following structure was obtained,The yield is 96%.
References:
CN111825633,2020,A Location in patent:Paragraph 0014
2114-02-5
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$6.00/10g
70-11-1
287 suppliers
$10.00/25g
2507-81-5
13 suppliers
$315.00/500mg