IMIDAZOLE-D4 synthesis

Yield:6923-01-9 99%

Reaction Conditions:

with water-d2;aluminium;platinum on carbon at 200; for 1 h;Microwave irradiation;

Steps:

15
Example 15 68 mg of imidazole, 10 mg of palladium-activated carbon (5%), and 10 mg of aluminum powder were added to 3 ml of heavy water, and the resulting mixture was subjected to microwave irradiation at 200° C. for 60 minutes. ¹H-NMR measurements (DMSO-d₆) were carried out through the same operations as those described in Example 1. As a result, it was confirmed that the isolated yield of the deuterated compound was 99.0%. Moreover, it was confirmed that the deuteration ratios of the hydrogen atoms (1) to (3) were 98.3% ((1)-D), 96.1% ((2)-D), and 96.1% ((3)-D), respectively. Here, the hydrogen atoms (1) to (3) respectively correspond to the deuterium atoms (1) to (3) in the target product shown below.

References:

Shimodaira, Haruki;Abe, Toshifumi;Miyazawa, Akira;Kawanishi, Yuji;Abe, Taichi US2010/331540, 2010, A1 Location in patent:Page/Page column 10

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