ChemicalBook CAS DataBase List ISOBUTYL BENZOATE

ISOBUTYL BENZOATE synthesis

13synthesis methods

Product Name:ISOBUTYL BENZOATE
CAS Number:120-50-3
Molecular formula:C11H14O2
Molecular Weight:178.23

From benzoic acid and isobutyl alcohol in the presence of HCl catalyst, or by ester exchange between methylbenzoate and isobutyl alcohol in the presence of potassium isobutylate

78-83-1 Synthesis

78-83-1
813 suppliers
$14.00/5mL

65-85-0 Synthesis

65-85-0
1442 suppliers
$10.00/25 g

120-50-3
167 suppliers
$16.60/25g

Yield:120-50-3 97%

Reaction Conditions:

with sulfuric acid;acetonitrile at 80 - 85; for 16 - 18 h;

Steps:

Procedure for ester (Table 2, entry 1-12 ):
General procedure: To a well-stirred mixture of acid (80 mmol), alcohol (90 mmol), acetonitrile (162 mmol) and sulfuric acid (98%, 94 mmol, 5 mL) was added at room temperature. Slowly heated to 80-85 °C and maintained between 80-85°C for16-18 h. The reaction mixture was cooled and added to 20% sodium carbonate solution (100mL). The reaction mass was extracted in CH2Cl2 (50 mL × 2). The combined organic layer was washed with water (100 mL), dried over sodium sufate, and concentrated under reduced pressure to obtain corresponding ester (97-99%) as the only product. Most example gave NMR pure product. Where minor impurities are formed, the product was purified over silica gel using ethyl acetate: petroleum ether (1:9).

References:

Dawar, Pankaj;Raju, M. Bagavan;Ramakrishna, Ramesha Andagar [Synthetic Communications,2014,vol. 44,# 6,p. 836 - 846] Location in patent:supporting information

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78-83-1 Synthesis

78-83-1
813 suppliers
$14.00/5mL

100-52-7 Synthesis