isopropyl N-4-chlorophenylcarbamate synthesis
- Product Name:isopropyl N-4-chlorophenylcarbamate
- CAS Number:2239-92-1
- Molecular formula:C10H12ClNO2
- Molecular Weight:213.66
Yield:2239-92-1 93%
Reaction Conditions:
at 90; for 3 h;Inert atmosphere;
Steps:
1-19 Production Example 1-19:
Synthesis of p-chloro-N-isopropoxycarbonylaniline
1.0 g (6.5 mmol) of p-chlorophenyl isocyanate and 2.0 g (33.3 mmol) of isopropanol were placed in a 15-mL test tube purged with nitrogen, and stirred at 90° C. for 3 hours.
The obtained reaction mixture was cooled to 25° C., and then dried under reduced pressure, thereby obtaining 1.3 g of a compound represented by the above formula (p-chloro-N-isopropoxycarbonylaniline) (yield: 93%).
The =H-NMR analysis results of the compound represented by the above formula are shown below.
1H-NMR (CDCl3) δ (ppm)=7.33 (d, J=8.6 Hz, 2H), 7.26 (d, J=9.1 Hz, 2H), 6.50 (s, 1H), 5.04-4.98 (m, 1H), 1.30 (d, J=6.3 Hz, 6H)
References:
US2020/24237,2020,A1 Location in patent:Paragraph 0177-0179
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