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ChemicalBook CAS DataBase List Isopropylbenzyl ether
937-54-2

Isopropylbenzyl ether synthesis

13synthesis methods
Isopropylbenzyl ether is produced 1) from Benzyl chloride and iso-propanol under alkaline conditions. 2) from Benzyl alcohol and iso-propanol by dehydration.
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Yield:937-54-2 100%

Reaction Conditions:

Stage #1: isopropyl alcoholwith sodium hydride in N,N-dimethyl-formamide;mineral oil at 0; for 0.5 h;Inert atmosphere;
Stage #2: benzyl bromide in N,N-dimethyl-formamide;mineral oil at 0 - 20; for 5 h;Inert atmosphere;

References:

Yasukawa, Naoki;Kanie, Takafumi;Kuwata, Marina;Monguchi, Yasunari;Sajiki, Hironao;Sawama, Yoshinari [Chemistry - A European Journal,2017,vol. 23,# 46,p. 10974 - 10977] Location in patent:supporting information