JP1302 synthesis
- Product Name:JP1302
- CAS Number:80259-18-3
- Molecular formula:C24H24N4
- Molecular Weight:368.47
1207-69-8
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$13.00/250mg
16153-81-4
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$9.00/250mg
80259-18-3
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Yield:80259-18-3 40 %
Reaction Conditions:
with hydrogenchloride in 1-methyl-pyrrolidin-2-one at 20;
Steps:
4.3. Synthesis of compounds 6a-e, 6m-z, 6 ab-aj
General procedure: To a solution of compound 4a-i (1 mmol) in NMP (3 mL) was added1-2 drops of concentrated hydrochloric acid and R3XH (2 mmol), andthe reaction mixture was stirred at room temperature. After completionof the reaction, and the reaction mixture was diluted with DCM (25 mL)and washed with brine (3 × 25 mL). The organic layer was dried overanhydrous MgSO4, filtered, and concentrated under vacuum. The residuewas purified by column chromatography to give the compounds 6ad,6j, 6m-z, 6 ab-aj.
References:
Liu, Hui-Min;Xiong, Xiao-Peng;Wu, Jiang-Wan;Chen, He-Xiang;Zhou, Ying;Ji, Shi-Kun;Dai, Xing-Jie;Zheng, Yi-Chao;Liu, Hong-Min [European Journal of Medicinal Chemistry,2023,vol. 251,art. no. 115255]
91-40-7
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80259-18-3
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62-53-3
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$10.00/1g
80259-18-3
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118-91-2
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$17.00/100g
80259-18-3
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