LCI699 synthesis
11synthesis methods
- Product Name:LCI699
- CAS Number:928134-65-0
- Molecular formula:C13H10FN3
- Molecular Weight:227.24
![Benzonitrile,4-[(5S)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-](/CAS/20180629/GIF/928134-66-1.gif)
Yield:-
Steps:
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 0 °C
2: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C
3: lithium hydroxide / tetrahydrofuran; ethanol / 1.5 h / 20 °C
4: ethanol / 3 h / 80 °C / Sealed tube
5: Resolution of racemate
References:
Meredith, Erik L.;Ksander, Gary;Monovich, Lauren G.;Papillon, Julien P. N.;Liu, Qian;Miranda, Karl;Morris, Patrick;Rao, Chang;Burgis, Robin;Capparelli, Michael;Hu, Qi-Ying;Singh, Alok;Rigel, Dean F.;Jeng, Arco Y.;Beil, Michael;Fu, Fumin;Hu, Chii-Whei;Lasala, Daniel [ACS Medicinal Chemistry Letters,2013,vol. 4,# 12,p. 1203 - 1207]
